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Over the past several decades, significant advances in stem cell biology have allowed the creation of cell replacement strategies to treat retinal degenerative diseases. Embryonic stem cells and induced pluripotent stem cells have become promising sources of a variety of retinal tissue components.
Age-related macular degeneration has received attention as a target disease because of the large unmet medical need associated with non-neovascular AMD. While AMD is a multifactorial disease, the dysfunction and ultimate loss of the retinal pigment epithelium is a major milestone in the progression of the disease and is highly correlated with vision loss.
Based on current clinical trials, it’s clear that stem cell–derived RPE transplantation in the subretinal space is possible and offers a potential therapy for disorders impacting the RPE.
This Focal Points module lists possible stem cell sources, discusses the surgical approaches used in recent retinal cell–based therapy clinical trials and examines the potential risks of the reviewed therapies.
By completing this module, you will be able to:
Authors: Jeremy Uang, BS; Amir H. Kashani, MD, PhD
Focal Points issues review the most crucial advances and feature insights to help you integrate tested research into your practice.
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This issue includes an audio version.
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The American Academy of Ophthalmology is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
The American Academy of Ophthalmology designates this enduring material for a maximum of 2 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.